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Cell Proliferation Studies in Syrian Hamsters following Vinblastine Treatment

Oncological Research Institute, 56, Sofia, Bulgaria

The dose-effect and the time-effect of i.p. injected Velbe (vinblastine sulfate, Lilly) on mitotic cells were studied in normal and tumorous hamster tissues. A dose of 1 mg/kg of body weight appeared suitable to jejunal crypt cells while most blocked metaphases in skin and cheek-pouch epithelium were counted at doses of 1.5 mg/kg and 5 mg/kg respectively. Metaphase increment in the jejunal crypts showed an approximately linear pattern up to the 4th hour, followed by a decrement at the 6th and 8th hours after the injection. Decrement was also noticed in stratified epithelium examined at the 9th hour. A striking stability of the prophase counts characterized the results obtained from all tissues examined. Velbe blocked mitoses in early or middle metaphases. The latter were normally detected as ball forms. Manifest cell degeneration was observed only in crypt cells following doses over 1 mg/kg and treatment longer than 3–4 hours.

Received 9/18/67. Accepted 1/15/68.