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Enhancement of Friend and Rauscher Leukemia Virus Replication in Mice by Guaroa Virus¹

Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health (W.T. and M.A.C.), and Microbiological Associates, Inc. (D.S.), Bethesda, Maryland 20014

Guaroa virus, a member of the Bunyamwera group of Arboviruses, which possesses physical and chemical characteristics similar to murine leukemogenic viruses, was studied to assess its effect on leukemia virus replication. Preinfection with Guaroa virus resulted in a markedly enhanced replication of Friend and Rauscher leukemia viruses. Enhanced virus replication was determined by use of three parameters: splenomegaly, spleen foci formation, and virus titer as detemined by bioassay. Relationships of the observed viral enhancement with other reported virus systems exhibiting enhancement are discussed.

¹ This investigation was supported, in part, by the National Cancer Institute, USPHS Contract No. PH-43-66-887 at Microbiological Associates, Inc., Bethesda, Maryland.

Received 11/14/67. Accepted 2/18/68.

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