This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Adams, R. A. Articles by Davis, B. J. Search for Related Content PubMed PubMed Citation Articles by Adams, R. A. Articles by Davis, B. J.

Direct Implantation and Serial Transplantation of Human Acute Lymphoblastic Leukemia in Hamsters, SB-2¹

Laboratories of Immunogenetics and Tumor Transplantation, The Children's Cancer Research Foundation, and The Department of Pathology, Harvard Medical School, at The Children's Hospital, Boston, Massachusetts 02115

Human acute lymphoblastic leukemia cells have been established as a serially transplantable lymphosarcoma in newborn Syrian hamsters by the direct inoculation of cells from the peripheral blood of a boy in the terminal stages of lymphosarcoma. The experimental neoplasm, currently in its 70th serial passage, is metastatic and occasionally progresses to frank leukemia. In later passages, it has become transplantable in the newborn hamster every 10–12 days. Immunofluorescence evidence indicates that it is still composed of human cells after continued passage in the experimental host. Cytogenetic examination shows the cells to be of male human karyotype. Electron-microscopic examination reveals them to be free of morphologically recognizable virus.

¹ These studies were supported in part by research Grants C-6516 from the National Cancer Institute, and FR-05526 from the Division of Research Facilities and Resources, NIH; the legacy of Loula D. Lasker; the Albert and Mary Lasker Foundation, New York; and the Alvan T. and Viola D. Fuller Cancer Research Unit Grant, American Cancer Society (Massachusetts Division) Inc.

Received 12/20/67. Accepted 2/25/68.

This article has been cited by other articles:

				S. Galiegue-Zouitina, L. Delestre, C. Dupont, X. Troussard, and C. S. Shelley Underexpression of RhoH in Hairy Cell Leukemia Cancer Res., June 15, 2008; 68(12): 4531 - 4540. [Abstract] [Full Text] [PDF]

				P. Aplan, D. Lombardi, A. Ginsberg, J Cossman, V. Bertness, and I. Kirsch Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity Science, December 7, 1990; 250(4986): 1426 - 1429. [Abstract] [PDF]

				S Ramakrishnan and L. Houston Inhibition of human acute lymphoblastic leukemia cells by immunotoxins: potentiation by chloroquine Science, January 6, 1984; 223(4631): 58 - 61. [Abstract] [PDF]