This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mauro, F. Articles by Sakamoto, K. Search for Related Content PubMed PubMed Citation Articles by Mauro, F. Articles by Sakamoto, K.

Comparison of Survival Kinetics and Modifications of Lethal Damage in Cultured Chinese Hamster Cells Exposed to Sulfur Mustard and X-rays^{1 ,2}

Radiation Biology Section, Laboratory of Physiology, National Cancer Institute, Bethesda, Maryland 20014

The lethal properties of the bifunctional alkylating agent sulfur mustard are compared to X-rays in cultured Chinese hamster cells. Survival curves and their dependence on pre- and post-treatment medium and temperature are presented. The results show that temperature and medium changes effected within 30 min after sulfur mustard treatment can bring about large shifts in the survival of surface-attached cells. In contrast, similar environmental changes produce only minor shifts in survival after X-irradiation. These and other results to be reported suggest some qualitative differences in the actions of sulfur mustard and X-rays.

¹ Some of these studies were first reported at the May 1967 Annual Meetings of the Radiation Research Society (See Ref. 15).

² We gratefully acknowledge postdoctoral support for F. Mauro from the Institute of Genetics, University of Rome and Consiglio Nazionale delle Ricerche, Rome, and the NIH, Bethesda, Md.; and for K. Sakamoto from the Damon Runyon Memorial Fund for Cancer Research, New York.

³ Present address: Division of Radiation Biology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo. 63110.

Received 11/ 7/67. Accepted 2/22/68.