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Differences in Survival Variations during the Growth Cycle of Cultured Chinese Hamster Cells Treated with Sulfur Mustard and X-rays¹

Radiation Biology Section, Laboratory of Physiology, National Cancer Institute, Bethesda, Maryland 20014

Although the survival of surface-attached Chinese hamster cells varies through the growth cycle after either X-irradiation or sulfur mustard treatment, the variations differ. Cells in the latter part of the DNA synthetic phase yield maximum survival after X-rays, while cells in the postsynthetic phase are the most resistant after sulfur mustard. As a result, when asynchronous cells are treated with either agent, they are rendered partially synchronized although out of phase.

The differences in the cyclic variations of survival after treatment with sulfur mustard compared to X-rays indicates that the damaging influences of these agents cannot be the same in all respects.

¹ We gratefully acknowledge postdoctoral support for F. Mauro from the Institute of Genetics, University of Rome and Consiglio Nazionale delle Ricerche, Rome, and the NIH, Bethesda, Maryland.

² Present address: Division of Radiation Biology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo. 63110.

Received 11/ 7/67. Accepted 2/22/68.