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Tumorigenicity of N-Nitrosohexamethyleneimine¹

Division of Oncology, The Chicago Medical School, Chicago, Illinois 60612

A new carcinogen, N-nitrosohexamethyleneimine (N-nitrosoperhydroazepine), was synthesized and given to rats of both sexes. The incidence of mixed malignant liver cell carcinomas and endothelial sarcomas was virtually 100% when the drug was given at 200 mg/liter for 8 weeks, while benign and malignant epitheliomas of the tongue or esophagus occurred in about 30%. When the drug concentration was 50 mg/liter given continuously over the life-span of the animals, the incidence pattern of tumors in liver and upper alimentary tract was reversed. The possible relevance of the types and distribution of these cancers to interpretations of the mechanism of action is discussed.

¹ This work was supported by USPHS Contract #43-65-67 from the National Cancer Institute, and by grants from the Cancer Society of New Zealand.

² Present address: National Cancer Research Laboratories, University of Otago, New Zealand.

³ Recipient of a Research Career Development Award, USPHS.

⁴ Present address: World Health Organization, 16; Avenue Marechal Foch, 69 Lyon, France.

Received 8/22/67. Accepted 4/ 1/68.