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Finney-Howell Cancer Research Laboratory, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 and Department of Gynecology and Obstetrics, Marquette School of Medicine, Milwaukee, Wisconsin 53226
A human hormone-synthesizing trophoblastic cell system has been established in vitro and may prove to be the first functional human embryonic cell line in continuous culture. Chorionic gonadotropin hormone produced by these cultures serve as a marker for identification of the trophoblastic cell. No interruption in this property nor change in cytologic display has occurred during 1.5 years in continuous culture. The continued proliferation of the undifferentiated cytotrophoblast is being stabilized in serial cultivation.
1 This research was supported in part by Public Health Contract No. 43-64-52, Damon Runyon Fund, American Cancer Society (E-273-1), and Milwaukee Division and Council for Tobacco Research.
2 Present address: Marquette School of Medicine, Department of Gynecology and Obstetrics, 8700 West Wisconsin Avenue, Milwaukee, Wisconsin 53226.
Received 12/18/67. Accepted 4/ 1/68.
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