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[Cancer Research 28, 1300-1310, July 1, 1968]
© 1968 American Association for Cancer Research
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Surface IgM-kappa Specificity on a Burkitt Lymphoma Cell In Vivo and in Derived Culture Lines1

Eva Klein, George Klein, Jagadish S. Nadkarni2, Jayshree J. Nadkarni2, Hans Wigzell and Peter Clifford

Department of Tumor Biology, Karolinska Institutet, Stockholm 60, Sweden, and Department of Head and Neck Surgery, Kenyatta National Hospital, Nairobi, Kenya

An exceptional Burkitt lymphoma patient, a 16-year-old boy, yielded tumor biopsy cells and derived tissue culture lines that displayed a strong surface accumulation of IgM heavy and kappa light chain specificities judged by direct membrane fluorescence and cytotoxicity tests. This property was maintained unchanged in the course of more than 5 months of serial passage in vitro. A fourth biopsy, obtained from the patient after massive necrosis had been induced in the tumor by cytosine arabinoside chemotherapy, did not show this property at either the biopsy stage or in the derived cell line. The possibility that the neoplastic transformation of lymphoid cells may have afflicted a cell specialized to carry immunoglobulin on its surface may be considered. The phenomenon has to be distinguished from immunoglobulin coating in vivo seen with certain biopsy samples from this and other patients. The latter type of coating can be of IgM, IgG, or IgA nature and disappears rapidly on cultivation in vitro.

1 This work has been supported by grants from the Swedish Cancer Society, the Jane Coffin Childs Memorial Fund, by Grant CA-04747 from the National Cancer Institute, USPHS, the British Empire Cancer Campaign, and the Lotter Bohmans Fund.

2 Fellows of the Swedish International Development Authority (SIDA) on leave from Indian Cancer Research Centre, Bombay.




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Copyright © 1968 by the American Association for Cancer Research.