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Virologic Studies in Human Leukemia and Lymphoma: The Herpes-type Virus

National Cancer Institute, Bethesda, Maryland

Selected background information is presented and discussed in the light of newer facts and leads from studies constituting a broad effort aimed at determining whether viruses similar (or different) to those known to be associated with the induction of leukemia and lymphoma in laboratory and domestic animals are also involved in the etiology of human leukemia and lymphoma. Emphasis was placed on studies concerning the establishment and experimental use of hematopoietic cell lines and of a herpes-type virus frequently associated with the cultures. Based on information published or contributed to the Special Virus-Leukemia Program of the National Cancer Institute, as of July 1967, over 125 cell strains have been established from patients with cancer or other diseases and from nondiseased controls. At least 61 of the "cancer" and 5 of the "noncancer" derived lines show herpes-type virus by electron microscopy. The virus(es) has been detected in cultures from patients and controls in laboratories in England, United States, Africa, Australia, New Guinea, Japan, and Sweden, and in the United States from several chimpanzees and 1 rhesus monkey—the latter with myeloid leukemia.

That the significance of these and other findings to cancer etiology remains unknown is discussed in relation to key studies that rapidly advancing technology and production of industrial quantities of virus will make possible.

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