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The Study of Normal and Malignant Cell Antigens by Mixed Agglutination¹

Department of Microbiology and Immunology, Division of Immunology, Duke University Medical Center, Durham, North Carolina

Mixed agglutination is a sensitive and valuable technic for studying cell antigens. The historic development, applications, and modifications of this method are discussed. New data are presented on the use of this procedure for studying the virus-specific cell surface antigens associated with transformation by SV40 virus. The pattern of reactivity of human cells with a panel of human isoantisera is not changed by transformation caused by SV40 virus.

¹ Supported by Grant CA-08975 from the National Cancer Institute and Grant T-234 from the American Cancer Society.

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