This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lewis, D. V. Articles by Edlich, R. F. Search for Related Content PubMed PubMed Citation Articles by Lewis, D. V. Articles by Edlich, R. F.

Studies on the Distribution of Blood Flow in Amelanotic Melanoma and Reticulum Cell Lymphosarcoma during Growth

Department of Surgery, University Hospitals, University of Minnesota, Minneapolis, Minnesota 55455

The distribution of intravenously administered ¹⁶⁹Yb microspheres, ⁸⁶RbCl, and a vital staining dye has been examined in amelanotic melanoma and reticulum cell lymphosarcoma of the hamster. The intensity of the dye stain within the tumor tissue was proportional to the uptake of the isotopic indicators by the tissue. Intensely stained tumor tissue has a significantly greater uptake of ¹⁶⁹Yb microspheres and ⁸⁶Rb than the unstained tumor tissue. The quantity of intensely stained tumor tissue varied with tumor type and size. In amelanotic melanoma, the total amount of intensely stained tumor tissue reached a maximum and remained nearly constant with increasing age. Further increase in tumor weight was due to an expanding central core of unstained tumor tissue which comprised approximately 82% of the total tumor mass.

The uptake of dye in reticulum cell lymphosarcoma was uniform in all small tumors. The amount of intensely stained viable tumor continued to increase in size during growth. In the large reticulum cell lymphosarcomas, stained tumor comprised 87% of the total tumor weight.

Received 11/13/67. Accepted 4/ 6/68.