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Antitumor Effect of Intracutaneous Injection of Bacterial Lipopolysaccharide¹

Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Tokyo, Japan

Intracutaneous injection of the lipopolysaccharide of Proteus vulgaris was found to stimulate the reticuloendothelial system and have a marked antitumor effect in mice bearing solid-type Ehrlich carcinoma and Sarcoma 180. The stimulation of the reticuloendothelial system was tested by measuring the clearing activity of intravenously injected colloidal carbon in mice. Of the various routes of injection tested, the actions of lipopolysaccharide were observed most after intracutaneous injection. Two possible modes of action of lipopolysaccharide were indicated: one is a stimulation of the reticuloendothelial system which can be expected to provoke subsequent antibody formation, and the other action is a direct cytocidal action.

¹ Aided by a grant from the Ministry of Education of Japan.

Received 12/11/67. Accepted 4/14/68.

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