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Influence of Hormonal Treatment of Fischer Rats on the Biochemistry of a Transplantable Dimethylbenz(a)anthracene-induced Mammary Carcinoma and Its Sublines¹

Squibb Institute for Medical Research, New Brunswick, New Jersey 08903 [R. H., L. J. L., I. M., C. B., H. G.], and Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121 [A.S., and R. J.]

Selected enzyme activities and nucleic acid content of the transplantable, dimethylbenz(a)anthracene-induced 13762 mammary adenocarcinoma and 3 sublines were measured as influenced either by the sex of the tumor-bearing host or by treatment of the host with androgen or estrogen. The normal female line tumor had the highest enzyme activities and the normal male line tumor had the lowest enzyme activities when growing in their respective hosts. Transplantation of these neoplasms into animals of the opposite sex produced either increased or decreased enzyme activities in direction of the normal tumor lines of the respective hosts. The tumor, conditioned by testosterone propionate, grew more rapidly in the presence of exogenous androgen and showed marked elevations in enzyme activities in comparison with those of the conditioned tumor line in the absence of hormone treatment. In general, the alterations in enzyme activities reflected the increased or decreased growth rate resulting from hormonal treatment. The exception to this was the response of the androgen-conditioned line to treatment with estrogen; this treatment produced no increase in tumor weight, but it increased enzyme activities and induced gross lactation. Continuous treatment with testosterone propionate for 5, 6, and 7 weeks in animals bearing the testosterone propionate-conditioned tumor resulted in a progressive increase in the activity of glucose-6-phosphate dehydrogenase, malate dehydrogenase, and -glycerolphosphate dehydrogenase.

¹ This work performed under Contracts SA-43-ph-2395 and PH-43-65-1050, Endocrine Evaluation Branch, General Laboratories and Clinics, National Cancer Institute, National Institutes of Health, Bethesda, Md.

Received 12/14/67. Accepted 4/ 6/68.