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Electrophoretic Mobility of Ehrlich Ascites Carcinoma Cells Grown in Vitro or in Vivo¹

Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, New York 14203

The mean electrophoretic mobility of Ehrlich ascites tumor cell populations varies during growth in vivo. The mean mobility reaches a maximum one to two days after tumor inoculation and then declines until death of the animals occurs. It is suggested, from measurements of cells after neuraminidase and/or ribonuclease treatment, that changes in the density of peripheral ionogenic groups susceptible to ribonuclease are responsible for the variations in mobility.

¹ Supported in part by Grant P-403 A from the American Cancer Society.

Received 11/14/67. Accepted 4/20/68.