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Further Studies on the Erythrocytic Host Response in Moloney Murine Leukemia

Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014

The red blood cells of 2-day-old normal and 8-week-old Moloney leukemia-infected BALB/c mice were examined using fragiligraphy, electron microscopy, and hemoglobin electrophoresis. Results of fragiligraphy revealed similar bimodal curves representing two RBC populations for the young normal and adult leukemic animals. Electron microscopy confirmed these two populations and revealed similarities in morphology between RBC's from the 2-day-old normals and 8-week-old leukemic animals. Electrophoresis showed no evidence of fetal hemoglobin in any of the samples. Thus, it is assumed the cells from the osmotically more resistant second populations in the leukemic animals are not fetal type cells in the sense of hemoglobin-types, but similar to the fetal erythrocytes which start to develop in the fetal liver (12th to at least the 17th day of gestation) and subsequently in the fetal bone marrow (after Day 16).

¹ Present address: Department of Zoology, University of Hawaii, Honolulu, Hawaii 96822.

² Present address: The Hebrew University of Jerusalem Faculty of Agriculture, Rehovot, Israel.

Received 11/13/67. Accepted 4/22/68.