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Effects of Hydroxyurea on Polyoma Virus Replication¹

Departments of Chemistry II and Tumor Biology, Karolinska Institutet, Stockholm 60, Sweden

Hydroxyurea inhibits DNA synthesis and growth of mouse embryonic and kidney cells. It is also an effective inhibitor of polyoma virus synthesis in these cells. Uninfected embryo cells are more sensitive to hydroxyurea than infected ones. Several different parameters of polyoma infection, i.e., DNA synthesis, infectivity, and capsid protein formation are affected similarly by hydroxyurea.

¹ This work was supported by grants from the Swedish Cancer Society, Grant CA-04747 from the National Cancer Institute, USPHS, the Damon Runyon Memorial Fund, and Knut and Alice Wallenbergs Foundation.

² Leave of absence from the Sloan-Kettering Institute for Cancer Research during the tenure of an Alfred P. Sloan Award in Cancer Research July 1966 to August 1967.

³ Address reprint requests to Dr. Irwin H. Krakoff, Sloan-Kettering Institute, 410 E. 68th St., New York, N.Y. 10021.

Received 2/ 7/68. Accepted 5/14/68.