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A Study of Clustering of Childhood Leukemia by Hospital of Birth¹

Department of Preventive Medicine, University of Utah College of Medicine, Salt Lake City, Utah 84112

An attempt was made to obtain epidemiologic evidence that the newborn human may be particularly susceptible to leukemogenic agents, perhpas leukemogenic viruses. The latter has been well established in some animal species. To this end an investigation was undertaken to try to detect clustering by hospital of birth of 234 children who died of leukemia before age 5 years out of approximately 1,000,000 children born in California hospitals in the years 1958–1960. In addition a method of Mantel was used to test for within-hospital clustering of day of birth for leukemia cases. No significant clustering was detected.

¹ This investigation was supported by USPHS Grant CA-05924 from the National Cancer Institute.

Received 12/26/67. Accepted 5/ 9/68.