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On Molecular Sizes of Rat Liver Arginase¹

The Institute for Cancer Research, Fox Chase, Philadelphia, Pennsylvania 19111

Arginase exists as 2 or more molecular species in the size profile of the soluble macromolecules of rat liver in the absence of added Mn⁺⁺. The principal species is that of approximately 120,000 molecular weight, as previously reported by others. In addition, after activation by Mn⁺⁺, there are detectable small but significant amounts of arginase of about 30,000–40,000 molecular weight, presumed to be the enzyme subunit. The relevance of the present finding to aminoazo dye hepatocarcinogenesis is considered.

¹ This investigation was supported in part by USPHS grants CA-05945, CA-06927, and FR-05539 from the National Cancer Institute and by an appropriation from the Commonwealth of Pennsylvania.

Received 7/31/68. Accepted 9/26/68.