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Fine Structure of Murine Pulmonary Adenomata Induced by Carcinogen Treatment in Organ Culture

Department of Experimental Pathology and Cancer Research, Medical School, University of Leeds, Leeds, England

Observations were made on early pulmonary adenomata induced by the exposure of mouse lung tissue to a carcinogen in organ culture and its subsequent subcutaneous implantation into host animals. The adenoma cells appeared to be derived from type II alveolar cells and showed a high degree of differentiation at the ultrastructural level. The procedure used permitted the study of early lesions, microscopic in size. These lesions, however, were of the same basic type which is produced by conventional in vivo methods of pulmonary tumor induction in mice.

¹ Present address: Department of Pathology, University of Bristol, Bristol, England.

Received 12/13/68. Accepted 6/10/69.