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Chemotherapy and Comparative Biochemistry: G. H. A. Clowes Memorial Lecture¹

Wellcome Research Laboratories, Burroughs Wellcome & Co. (U.S.A.) Inc., Tuckahoe, New York 10707

A program in chemotherapy is descibed, which is based on the purposeful exploration of enzymes and metabolic pathways by means of antimetabolites. This program has led to the development of drugs for leukemia, gout and hyperuricemia, protozoal and bacterial infections, and autoimmune diseases and the control of immune responses in transplantation.

¹ Presented at the 59th Annual Meeting of the American Associatic for Cancer Research, April 1968, Atlantic City, New Jersey.

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