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Inhibition of the Growth of Mouse Melanoma by Chlorpromazine¹

Departments of Internal Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

The effects of three phenothiazines, chlorpromazine (CPZ), chlorpromazine sulfoxide (CPZ-O), and 7-hydroxychlorpromazine (7-OH-CPZ), on the growth of B-16 and Harding-Passey mouse melanomas were investigated. CPZ and 7-OH-CPZ both inhibited tumor growth, but CPZ-O did not. The melanoma tyrosinase was activated by CPZ both in vivo and in vitro. There was no significant effect of CPZ on the succinic oxidase and reduced nicotinamide adenine dinucleotide oxidase of either the melanoma or liver of these animals. The marked affinity of phenothiazines for melanin might be used to develop more effective melanoma chemotherapeutic agents.

¹ This work was supported by USPHS Grant NB07542-01.

Received 1/21/69. Accepted 3/27/69.