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The Production of Hemangioendothelialsarcoma in Rats by Feeding 5-Acetamido-3-(5-nitro-2-furyl)-6H-1,2,4-oxadiazine¹

The Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706 [E. E., S. M. C., G. T. B.] and Scientific Divisions, Abbott Laboratories, North Chicago, Illinois 60064 [J. M. P., A. M. V., A. J. C.]

Thirty-five female Sprague-Dawley weanling rats were fed 5-acetamido-3-(5-nitro-2-furyl)-6H-1,2,4-oxadiazine for 37 weeks. All 32 rats surviving 28 weeks or more developed hemangioendothelialsarcomas at one or more sites. These unusual tumors were located in the livers of 31 rats, in the mesentery of 30 rats, and in the lungs of 5 rats. Nine rats developed alveolar carcinomas, and 1 rat developed a benign fibroadenoma of the mammary gland. The distribution of tumors observed following the administration of this nitrofuran derivative was surprisingly different from that observed after feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide, a potent urinary bladder carcinogen for the rat.

¹ Supported in part by a grant from the American Cancer Society (E-116J), The Wisconsin Division of the American Cancer Society, and Contract No. PH 43-66-888 and Grant No. CA-10017 from the National Cancer Institute, NIH.

² Medical Scientist Trainee of the National Institute of General Medical Sciences (GM-01932).

³ Career Development Awardee of the National Cancer Institute (CA-8245-01A1).

Received 3/ 6/69. Accepted 4/24/69.