This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Sartorelli, A. C. Search for Related Content PubMed PubMed Citation Articles by Sartorelli, A. C.

Some Approaches to the Therapeutic Exploitation of Metabolic Sites of Vulnerability of Neoplastic Cells¹

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

Some experimental approaches designed to attain more potent therapies for the treatment of malignant diseases have been described. It is suggested that the therapeutic potency of agents, with known utility in the treatment of tumors in man, can conceivably be enhanced by capitalizing further on known metabolic sites of vulnerability of tumor cells, either by the rational modification of existing antineoplastic agents or by their use in combination with other drugs to achieve greater biochemical alteration of metabolic processes. Several theories predictive of enhanced activity by two agents in combination are described. These include the application of the concepts of sequential, concurrent, and complementary inhibition to the treatment of neoplastic disease.

¹ Support was provided by Grant CA-02817 from the National Cancer Institute, USPHS, and Grant T-23 from the American Cancer Society.