This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Moore, E. C. Search for Related Content PubMed PubMed Citation Articles by Moore, E. C.

The Effects of Ferrous Ion and Dithioerythritol on Inhibition by Hydroxyurea of Ribonucleotide Reductase¹

The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

Inhibition by hydroxyurea of partially purified ribonucleotide reductase from rat tumor was studied in vitro. The inhibition was partially reversed by ferrous ions. At maximum iron concentration, further reversal by increased dithioerythritol was observed. No chemical reaction of hydroxyurea with either dithioerythritol or iron could be demonstrated. The ribonucleotide reductase of Escherichia coli, which is not stimulated by added iron, was much less sensitive to hydroxyurea, and this inhibition was not reversed by dithioerythritol.

¹ This investigation was supported by USPHS Grant No. CA-04464 from the National Cancer Institute.

Received 5/29/68. Accepted 10/19/68.