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The Effect of Treatment with a Combination of 6-Mercaptopurine and Porfiromycin on an Established Friend Leukemia Virus Infection¹

Virus Section, Chemotherapy Research Department, Southern Research Institute, Birmingham, Alabama 35205

The effect of parenteral therapy with combinations of 6-mercaptopurine and porfiromycin on established infections of Friend leukemia virus in Swiss mice was studied. In one experiment both drugs were markedly effective in reducing virusinduced splenomegaly and virus titers in the plasma and spleens, but treatment with the combination of drugs was more effective than treatment with either drug used alone, when comparative nonlethal drug levels were used. In a second experiment these results were confirmed, and reduction in blood hematocrit values and in hepatomegaly were used successfully as additional criteria for evaluation. In all experiments treatment was not initiated until 14 days after virus inoculation when the virus infection was established in the animals as shown by demonstrable splenomegaly and spleen and plasma virus titers.

¹ Supported by Contract PH-43-63-68 from the Cancer Chemotherapy National Service Center, National Cancer Institute, USPHS.

Received 7/25/68. Accepted 11/ 7/68.