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An Immunochemotherapeutic System for the Treatment of a Transplanted Moloney Virus-induced Lymphoma in Mice

Drug Evaluation Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014

The development of a system for the combined immunochemotherapeutic treatment of a lymphoma of BALB/c mice induced by Moloney virus is presented. Allogeneic cells specifically sensitized to the Moloney virus-induced transplantation antigen(s) in conjunction with Cytoxan can be used successfully to eradicate the lymphoma in a significant proportion of the animals. Cytoxan alone, while providing marked increases in survival time, did not eradicate the tumor. Treatment with the sensitized allogeneic cells alone was without effect.

¹ Present address: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

² Present address: Department of Medicine, University of Washington School of Medicine, Seattle, Washington.

Received 7/ 1/68. Accepted 11/ 6/68.