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The Morphology and Growth Characteristics of Radiation-induced Epithelial Skin Tumors in the Rat¹

Institute of Environmental Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016

The histology of radiation-induced epithelial skin tumors in the albino rat is described in terms of various types of nondifferentiated, sebaceous, and keratinized tumors. The frequency distribution, growth rate, and time of onset of these tumors are shown to be related to the magnitude of residual skin damage. Tumors are shown to form periodically with peak rates in the domain of 20, 40, and 60 weeks after irradiation. Evidence is presented which suggests that the structure of skin tumors is explained in terms of their origin from atrophic follicles.

¹ This investigation was supported by a project grant from the Atomic Energy Commission, Grant No. AT(30-1)2785, and is part of a core program supported by the USPHS Bureau of State Services, Institutes of Environmental Health, Grant No. ES 00014, and the National Cancer Institute, Grant No. CA 06989.

² Department of Pathology, New York University Medical Center.

³ Department of Biophysics, Institute of Cancer Research, Royal Cancer Hospital, Clifton Avenue, Belmont, Sutton, Surrey, England.

⁴ Air Force Weapons Laboratory, Kirtland Air Force Base, New Mexico.

Received 6/26/68. Accepted 10/30/68.