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The Proportionality of Glutaminase Content to Growth Rate and Morphology of Rat Neoplasms¹

The Cancer Research Institute, New England Deaconess Hospital, the Department of Biological Chemistry, Harvard Medical School, and the Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02215

Correlations were demonstrated among the growth rates, concentrations of kidney-type of phosphate-dependent glutaminase, and morphologies of seven types of transplanted and primary rat neoplasms. The exponential rates of growth in volume of each of the transplanted rat neoplasms were respectively similar to their rates of cellular growth, measured with colchicine. The relative degrees of histologic differentiation were quantified by a ranking procedure. The concentrations of enzyme present in the tumors were proportional to the rates of growth over the 5-fold ranges encompassed by this material, and the faster growing tumors with more enzyme were proportionately more undifferentiated. The glutaminase apparently plays a significant role in neoplastic type of metabolism in this series of heterogeneous tumors because it is quantitatively proportional to the two main biologic properties of these neoplasms.

¹ This investigation was supported by USPHS Grant CA-06993, General Research Support Grant of the National Cancer Institute, by Research Career Award AM-K6-2018 from the National Institute of Arthritis and Metabolic Diseases, both of the NIH, and by U. S. Atomic Energy Commission Contracts AT(30-1)-3777 and AT(30-1)-3779 with the New England Deaconess Hospital.

Received 6/17/68. Accepted 11/ 6/68.

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