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Renal Epithelial Neoplasms Induced in Male Wistar Rats by Oral Aflatoxin B₁¹

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

Purified aflatoxin B₁ was added to the diet of male Wistar rats, at concentrations of 1.0, 0.5, and 0.25 parts per million for 147 days. The animals were then maintained until death on a basal diet. Renal epithelial neoplasias, histologically similar to human kidney adenocarcinoma, were found in over one-half of the animals ingesting the highest level of aflatoxin B₁ and in about one-quarter of the rats given the two lower dosages. Malignant hepatocellular carcinomas were also encountered in many of the animals although the renal tumors were present as the only neoplasia in some of the rats. The gross and microscopic appearance of the kidney tumors is described.

¹ This work was supported in part by a contract (PH-43 64 505) from the National Cancer Institute, by a research grant (G. M. 10269) from the National Institute of General Medical Sciences, and by a training grant (G. M.-135) from the National Institute of General Medical Sciences.

Received 10/17/68. Accepted 11/23/68.

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