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A Ten-Year Study of 5-Fluorouracil in Disseminated Breast Cancer with Clinical Results and Survival Times¹

Division of Clinical Oncology, Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53706

The clinical results of 676 patients with widely disseminated breast cancer treated with 5-fluorouracil (5-FU) alone or with any additional therapy over the past ten years are presented. One observes a significantly increased survival in the 23.1 percent that improved and the 23.1 percent that were unchanged compared to the 53.8 percent that had progression on 5-FU therapy. To eliminate the beneficial influence on survival as a result of any other treatment, all patients who improved or were unchanged by other therapy were deleted, leaving a "corrected" group which showed a pattern almost identical to the overall total group, correlating increased survival with 5-FU responsiveness.

¹ This investigation was supported by the USPHS Research Grant No. CA 06749 from the National Cancer Institute.

² Career Development Awardee of the National Cancer Institute (1-K4 CA 8245-01A1).

Received 5/27/68. Accepted 12/18/68.