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Autologous Bone Marrow Grafts in Dogs Treated with Lethal Doses of Cyclophosphamide¹

Department of Medicine, University of Washington School of Medicine, and the USPHS Hospital, Seattle, Washington 98144

Dogs were given a single intravenous injection of 100 mg of cyclophosphamide per kilogram of body weight. Ten dogs received supportive therapy only and died within 14 days with profound marrow hypoplasia. Ten dogs were given stored autologous marrow 24 hours after administration of cyclophosphamide. Eight showed prompt hemopoietic recovery and survived. It was concluded that stored autologous bone marrow is effective in restoring hemopoietic function following an otherwise lethal dose of cyclophosphamide.

¹ This work was supported by USPHS Research Grant RH 00311, National Center for Radiological Health, and by Grant T-280 from the American Cancer Society.

² Supported by research career program award 1-K6-A1-2425 from the National Institute of Allergy and Infectious Diseases, NIH, USPHS.

Received 10/ 9/68. Accepted 12/ 6/68.

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