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Enhancement of Spleen Focus Formation and Virus Replication in Friend Virus-infected Mice¹

Department of Viral Oncology, Roswell Park Memorial Institute, Buffalo, New York 14203

Spleen focus formation, induced by a member [spleen focus-forming virus (SFFV)] of the Friend virus complex, was enhanced in mice that had been infected 2 days previously with Newcastle disease virus or lactic dehydrogenase-elevating virus. Enhancement was also observed in mice treated with erythropoietin or maintained in 10 percent oxygen for 48 hours before SFFV infection. Sublethally irradiated mice were able to synthesize 30 times as much SFFV after treatment with S. typhosa endotoxin. Evidence is presented which indicates that these treatments exert their effects, at least in part, by increasing the number or susceptibility of target cells for SFFV. The data are consistent with the hypothesis that a major portion of the target cells for SFFV are primitive erythroid cells, possibly erythropoietin-sensitive cells.

¹ This investigation was supported in part by the National Cancer Institute (USPHS research grants, CA-08847-02 and CA-07745-04), and by the United Health Foundation of Western New York (Grant G-R-68-RP-14).

Received 10/10/68. Accepted 12/22/68.

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