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Biologic Studies on 7,12-Dimethylbenz()anthracene-induced Rat Leukemia with Special Reference to the Specific Chromosomal Abnormalities¹

Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan

Biologic studies were made on rat leukemia with specific chromosomal abnormalities induced by pulse doses of 7,12-dimethylbenz()anthracene. The leukemia cells with a trisomy of the longest telocentric chromosome (C-1) were shown to be different in several hematologic and biologic characters from the leukemia cells with normal karyotype. The leukemia cells with C-1 trisomy were of erythroblast nature and showed maturation arrest at the stage of polychromatic normoblast. The characteristic natures of C-1 trisomy-positive cells were considerably modified by the presence of another additional trisomy of the 6th metacentric chromosome (A-6).

These facts evidently showed the influence of extra chromosomes on cell differentiation and further suggested that the unbalanced genetic constitution of a cell as revealed in the present experimental system is possibly related to malignant transformation of the cell.

¹ This study was partly supported by a Grant-in-Aid for Fundamental Research from the Ministry of Education.

² Present address: The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637. Reprint request should be addressed to this author.

Received 8/ 5/68. Accepted 12/24/68.