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Enhancement by Glucose of the Inhibition of an Ehrlich Ascites Tumor by Tetraazatricyclododecane¹

Department of Statistics and Biometry, School of Medicine, Emory University, Atlanta, Georgia 30322, and Kettering Laboratory, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45219

The survival of mice inoculated with Ehrlich ascites tumors was prolonged by the intraperitoneal injection on the following day of an isotonic solution of glucose (100 ml/kg) containing 1 to 2 millimoles of tetraazatricyclododecane per kg of body weight. The addition of tetraazatricyclododecane to the solution of glucose increased the average length of survival (geometric mean) from 18.0 to 149 days. When isotonic galactose or sodium chloride was substituted for glucose, the addition of tetraazatricyclododecane increased the average survival from 19.4 to 71.4 days. The difference between the two increases in survival has a probability of 1 in 50 of being due to chance alone. Similar injections made subcutaneously were ineffective.

¹ The analysis was done, in part, under NIH Training Grant Number GM 01204 from the National Institute of General Medical Sciences.

Received 7/18/68. Accepted 12/20/68.