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The Development of Carcinoma in Liver of Rats Treated with m-Toluylenediamine and the Synergistic and Antagonistic Effects with Other Chemicals

1st Department of Pathology, Nara Medical University, Kashihara, Nara, Japan

Carcinoma of the liver with invasion and metastases has been observed in rats fed diets containing 0.1 or 0.06 percent m-toluylenediamine. Histologically all the tumors were hepatocellular carcinomas closely resembling those following the administration of other hepatic chemical carcinogens. The simultaneous administration of DL-ethionine had a synergistic effect with m-toluylenediamine on liver tumor formation. In contrast, cancer induction was completely prevented by the concomitant feeding of 3-methylcholanthrene, alpha-naphthyl isothiocyanate, or p-hydroxypropiophenone and m-toluylenediamine.

Received 9/ 9/68. Accepted 12/25/68.

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