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The Susceptibility of Fetal Rat Skin in Different Immunologic Environments to Neoplastic Induction with Shope Papilloma Virus¹

Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033 and Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

The susceptibility of fetal rat skin to neoplastic induction with Shope papilloma virus (SPV) was studied. While a high proportion of fetal rat skin grafts infected with SPV and transplanted to the cheek pouches of cortisone-treated hamsters became papillomatous, only a small proportion of similar grafts placed in syngeneic rats became transformed. Those papillomas which did develop in the fetal rat skin grafts in syngeneic hosts always regressed. The regression was preceded and accompanied by a lymphocytic infiltration. An explanation for these observations may be that rats are capable of recognizing a new antigen in syngeneic epidermal cells transformed by SPV, and of subsequently mounting an effective immunologic attack against the papilloma cells.

¹ Supported by a grant from the USPHS (CA-10320-01).

Received 10/24/68. Accepted 1/ 2/69.