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Influence of Hypothalamic Lesions on the Induction and Growth of Mammary Cancers in Sprague-Dawley Rats Receiving 7,12-Dimethylbenz(a)anthracene¹

Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania 19140

Lesions of the median eminence of the tuber cinereum of the hypothalamus inhibit the induction of mammary cancer in Sprague-Dawley female rats that subsequently receive intragastric 7,12-dimethylbenz(a)anthracene. In contrast, such lesions significantly accelerate the growth of established mammary cancer and cancel the inhibiting effect of ovariectomy.

¹ This work was aided in part by Grant No. IN88 from the American Cancer Society and Grant No. CA-07771 from the National Cancer Institute, NIH, USPHS.

² Present Address: Smith, Kline and French Laboratories, Philadelphia, Pa. 19130.

Received 9/20/68. Accepted 12/24/68.