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Regeneration, Tumor, Dietary, and L-Asparaginase Effects on Asparagine Biosynthesis in Rat Liver

Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma 73401

The asparagine synthetase (EC.6.3.1.1) activity of rat liver was elevated during host tumor growth, regeneration, and nutritional deprivation of asparagine and by injections of L-asparaginase (EC.3.5.1.1); but it decreased during maturation. An evaluation of the effects of endogenous asparaginase and aspartic acid or asparagine pools on the assay system revealed that neither appreciably affected the results. A heat-labile inhibitor of asparagine synthesis, however, was found to be present in normal adult liver extracts.

Received 10/21/68. Accepted 12/21/68.