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Glutaminase Activities and Growth Rates of Rat Hepatomas¹

Department of Biological Chemistry, Harvard Medical School, and the Cancer Research Institute, New England Deaconess Hospital, Boston, Massachusetts 02215, and the National Cancer Institute, NIH, Bethesda, Maryland 20014

For a series of transplantable rat hepatomas, the growth rate, as well as the type and quantity of glutaminase activity, was determined. The times for volume doubling of the hepatomas ranged from 3 to 29 days. All but the slowest growing of the hepatomas contained the kidney, rather than the liver, type of phosphate-dependent glutaminase, and for these tumors the same correlation was found between enzyme activity and growth rate that was found for a previous series of nonhepatic tumors.

¹ This investigation was supported by USPHS Fellowship 1-F2-CA-17,695-01 from the National Cancer Institute (M. L-H.), USPHS Grant AM 00567, Research Career Award AM-K6-2018 from the NIH, United States Atomic Energy Commission Contract AT(30-1)-3779 with the New England Deaconess Hospital (W. E. K.), and USPHS Grant CA-10729 (H. P. M.).

Received 9/30/68. Accepted 2/ 5/69.

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