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Effect of Chemical Carcinogens on Virus-induced Rous Sarcoma¹

Institute of Microbiology, Rutgers University, New Brunswick, New Jersey 08903

In general, the effects of certain chemical carcinogens, known to be oncogenic in chickens, on virus-induced Rous sarcoma were not dramatic. Where cocarcinogenic effects were observed, they were most pronounced when the chemical carcinogen was injected after infection with Rous sarcoma virus. Cocarcinogenic effects were manifested primarily by more rapid tumor growth rather than be secondary tumor formation. Unusual tumor morphology was not observed. Of the carcinogens tested, 7,12-dimethylbenz(a)anthracene was the most effective cocarcinogen. N-2-fluorenylacetamide was cocarcinogenic when injected after virus but was inhibitory when administered prior to infection. Other samples enhancing virus-induced Rous sarcoma were 9,10-dimethyl-1,2-benzanthracene, benzo(a)pyrene, and 1,2,5,6-dibenzanthracene. 20-Methylcholanthrene was weakly cocarcinogenic.

¹ Aided by Grant #E-467 from the American Cancer Society.

² Present address: Microbiology Division, CIBA Pharmaceutical Company, Summit, New Jersey, 07901.

³ Present address: Life Sciences, Inc., 2900-72nd Street North, St. Petersburg, Florida 33710.

Received 10/ 7/68. Accepted 2/20/69.