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The Role of the Regional Lymph Nodes in the Immunity to a Chemically Induced Sarcoma in C3H Mice

Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014

The functional significance of the host's regional lymphoid tissues in the immunity to chemically induced tumors was studied in inbred C3H/HeN female mice using a 20-methylcholanthrene-induced sarcoma in its second and third transplant generations. Unilateral removal of the regional lymphoid tissues did not significantly alter host response to a primary chemically induced tumor cell inoculum injected either distal to the lymphadenectomy or in the contralateral hind limb. A regional lymphadenectomy had no effect on the growth of an established chemically induced tumor transplant, nor did it significantly alter an immunized host's response to a subsequent challenge with the same chemically induced tumor. Adoptive transfer of immunity to a chemically induced tumor was accomplished with regional lymph node cells from tumor-bearing animals when 10⁸ cells were administered intraperitoneally to previous untreated recipients.

¹ Present address: Boston Hospital for Women, Lying-In Division, Boston, Massachusetts 02115.

Received 9/10/68. Accepted 2/ 5/69.

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