This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lee, K. P. Articles by Olson, C. Search for Related Content PubMed PubMed Citation Articles by Lee, K. P. Articles by Olson, C.

Precipitin Response of Cattle to Bovine Papilloma Virus¹

Department of Veterinary Science, University of Wisconsin, Madison, Wisconsin 53706

Precipitins for bovine papilloma virus (BPV) which developed following experimental infection of 21 calves were characterized by diethylaminoethyl-cellulose chromatography, gel filtration with Sephadex G-200, sucrose density gradient, and analytic ultracentrifugation. A 19 S antibody alone was found 1 week after initial exposure to BPV which persisted at demonstrable levels for 8 weeks. Both 19 S and 7 S antibodies were found between 2 and 8 weeks. A 7 S antibody alone was consistently found in serums 16 weeks after the initial exposure to BPV. Precipitins appeared earlier than development of resistance to reinfection with BPV, and their presence in serum could not be correlated with growth or regression of the bovine fibropapillomas.

¹ Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part with the aid of Grant C 4627 of the NIH.

Received 8/15/68. Accepted 2/19/69.