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Skin Nucleic Acid Phosphorus Metabolism of DBA/1J Mice during Implanted Tumor Development and Methylcholanthrene Carcinogenesis¹

Department of Biology, North Texas State University, Denton, Texas 76203

Implanted tumors and methylcholanthrene carcinogenesis increase the turnover of phosphorus in the total nucleic acids of histologically normal DBA/1J mouse skin. As the implanted tumors progress for 6 days, the turnover rate of nucleic acid phosphorus in the histologically normal skin increases to 4 times that of control skin from normal DBA/1J mice. At this same time, 68% of the histologically normal skin implants from the tumor-bearing mice develop into lymphosarcomas when implanted into normal DBA/1J mice.

Painting mice on the dorsum with methylcholanthrene results in a decrease in the turnover rate of nucleic acid phosphorus of the painted skin. However, the nucleic acid phosphorus turnover of ventral unpainted skin from the same mice is increased as painting progresses. After six weeks of painting, the ventral unpainted skin, though histologically normal, develops into a lymphosarcoma when implanted into normal DBA/1J mice. This transplantability occurs after the appearance of papillomas on the painted area.

¹ This study was supported by funds from National Cancer Institute Grant Ca-07527, USPHS.

Received 1/ 9/68. Accepted 3/24/69.