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Response to Highly Purified L-Asparaginase during Therapy of Acute Leukemia¹

Wadley Institutes of Molecular Medicine, Dallas, Texas 75235

Seven of nineteen patients with acute lymphatic leukemia and eight of eighteen patients with acute granulocytic leukemia received L-asparaginase according to a daily dosage schedule of 2,000 IU or more per kg for twenty-one days or more. Six of the seven acute lymphatic leukemia patients and four of the eight acute granulocytic leukemia patients underwent a complete bone marrow remission. In contrast, only two patients with acute lymphatic leukemia and none of the patients with acute granulocytic leukemia obtained a complete remission at lower dosage levels. L-Asparaginase is relatively nontoxic and does not exhibit cross-resistance with conventional agents. Further study is merited in order to determine its ultimate effectiveness either alone in higher dosages or in combination with conventional agents.

¹ Read before the XIIth Congress of the International Society of Hematology, New York, N. Y., September 3, 1968. Address reprint requests to Dr. J. M. Hill, 9000 Harry Hines Blvd., Dallas, Texas 75235

² Scholar, Leukemia Society of America.

Received 11/12/68. Accepted 4/ 9/69.