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Fine Structure of a Transplanted Chemically Induced Nonlymphoid Thymoma¹

Department of Anatomy, Medical College of Ohio at Toledo, Toledo, Ohio 43614, and the Department of Laboratory Medicine, College of Medical Sciences, University of Minnesota, Minneapolis, Minnesota 55455

A chemically induced, serially transplanted nonlymphoid thymoma capable of immunologic restoration of neonatally thymectomized mice was examined by electron microscopy. The cytoplasm of most of the cells in this tumor is filled with single ribosomes and polysomes. A moderate amount of rough endoplasmic reticulum is present. Cells with the identifying characteristics of normal thymic epithelial cells are absent. Dense granules similar to those in thymic epithelial cells are observed in some tumor cells. Type A virus particles are present in association with rough endoplasmic reticulum.

¹ Aided by USPHS Grants CA-10445 and AM-13535.

Received 1/16/69. Accepted 5/19/69.