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Studies on the Oncogenicity of 3-Hydroxyxanthine¹

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, New York 10021

The oncogenicity of the purine N-oxide, 3-hydroxyxanthine, was tested in newborn and weanling ICR/Ha mice and in newborn, suckling, and weanling Wistar rats. Tumors were induced at the subcutaneous site of administration and occasionally in the liver; male rats were more susceptible than females. At the doses used, newborns of both species and weanling mice were less susceptible than weanling rats. The incidence of benign and malignant tumors at the subcutaneous site was dose dependent, and the latencies of the malignant tumors were generally shorter.

¹ This is Paper XXXI in the series entitled "Purine N-Oxides." Supported in part by National Cancer Institute Grant CA-08748.

Received 4/ 1/69. Accepted 5/26/69.

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				G. Stohrer and G. B. Brown Oncogenic Purine Derivatives: Evidence for a Possible Proximate Oncogen Science, March 20, 1970; 167(3925): 1622 - 1624. [Abstract] [PDF]