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Polyribosome Disaggregation in Rat Liver following Adminstration of Tannic Acid¹

Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City, Kansas 66103

Tannic acid, a naturally occurring hepatocarcinogen, caused marked disaggregation of polyribosomal patterns in rat liver commencing 3 hr after s.c. injection in a dose of 700 mg/kg body weight. Between 4 and 10 hr after the administration of tannic acid, disaggregation of the polyribosomes was complete, resulting in an increase in the monomer-dimers (80 to 110 S). These changes coincided in time with reduction in the amino acid incorporation in vivo and the ultrastructural changes in the rough endoplasmic reticulum of hepatic parenchymal cells. Partial recovery of the polyribosomal patterns and of the amino acid-incorporating activity in vivo was evident at 72 hr after the single injection of tannic acid.

¹ These studies were supported in part by USPHS Grants CA-5680, CA-8055, and GM-15956.

Received 3/14/69. Accepted 5/ 8/69.