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Absence of Alkaline Phosphatase in Rat Thymic Lymphoma Induced by Murine Leukemia Virus¹

Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California 94305

Alkaline phosphatase activity has been determined by a histochemical assay on thymic lymphomas induced by murine leukemia virus in C57BL mice and W/Fu rats. Approximately 60% of the former and none of the latter tumors showed this activity in the plasma membrane of the tumor cells. The possibility that the enzyme "activation" represents expression of a derepressed cell gene rather than of a viral gene is discussed.

¹ This investigation was supported by USPHS Research Grant CA 08914 from the National Cancer Institute and Training Grant AI-82 from the National Institute of Allergy and Infectious Diseases.

Received 3/26/70. Accepted 6/ 8/70.