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Susceptibility of Guinea Pigs to Chemical Carcinogens: 7,12-Dimethylbenz(a)anthracene and Urethan¹

The Eppley Institute for Research in Cancer, University of Nebraska College of Medicine, Omaha, Nebraska 68105

Single s.c. injections of 25, 20, 15, 10, 5, 1, and 0.1 mg 7,12-dimethylbenz(a)anthracene, administered at birth to randomly bred Hartley albino guinea pigs, resulted in the induction of various types of s.c. tumors at the injection site. In addition, malignant lymphomas, tumors of skin, lungs, uterus, ovaries, breast, etc., were also evoked by the treatment. Three i.v. injections of 3 mg 7,12-dimethylbenz(a)anthracene, given first at birth and on every third day, gave rise to higher incidences of tumors of the breast, lungs, uterus, ovaries, and skin than in the corresponding control groups. Five s.c. injections of 1 mg urethan/g body weight, administered similarly as in the previous group, produced tumors of lungs and ovaries.

In contrast to earlier reports, when the carcinogenic dose is expressed quantitatively on mg/g body weight basis, according to the present finding, the guinea pig was found to be at least as susceptible as the mouse to chemical stimulus.

¹ This investigation was supported by USPHS Grant CA-07007 and Contract PH 43-68-959 from the National Cancer Institute.

² Recipient of USPHS Research Career Development Award 1K04-Ca-42552-O1 from the National Cancer Institute, NIH.

Received 2/16/70. Accepted 7/ 1/70.