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The Refractoriness of the Skin of Hairless Mice to Chemical Carcinogenesis¹

McArdle Laboratory for Cancer Research, The Medical School, University of Wisconsin, Madison, Wisconsin 53706

The sensitivity to cutaneous chemical carcinogenesis of haired and hairless mice of the same strain has been compared. 9,10-Dimethyl-1,2-benzanthracene has been used as the initiator, and 0.5% croton oil in acetone has been used as the promotor. More than 29 weeks of this treatment produced a total of only 7 papillomas in 44 hairless mice, 87 papillomas and 3 carcinomas in their 13 haired siblings, and 127 papillomas and 9 carcinomas in 69 Swiss haired mice. Thus, the skin of haired mice is much more susceptible to chemical carcinogenesis than the skin of hairless mice. Traumatization of the skin did not alter these results. Newborn "haired" and "hairless" mice have equal amounts of hair during the first 2 weeks of life. If treated in the above manner during this period, they respond identically. These results stress the importance of the hair follicle and its appendages in cutaneous chemical carcinogenesis of the mouse.

¹ This work was supported in part by Grant CA 07175 from the National Cancer Institute, NIH. A preliminary report of part of this work has appeared (13).

² Present address: The Stehlin Foundation, 834 Hermann Professional Building, Houston, Texas 77025.

³ American Cancer Society Professor of Oncology.

Received 3/ 2/70. Accepted 7/ 1/70.

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